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Veterinary vaccine bottles: materials, production processes and quality standards explained

Aug. 19, 2024

Veterinary vaccine bottles are an indispensable and important part of veterinary medicine. With their specific materials, precise production processes and strict quality requirements, they provide reliable guarantees for the safe storage and effective vaccination of inactivated vaccines and vaccine diluents.

Specification and material introduction of plastic vaccine bottle

100ml PP vaccine vial

1. Materials and production processes

Veterinary vaccine bottles widely use two main materials, polyethylene and polypropylene. Polyethylene is suitable for long-term storage of liquid vaccines, while polypropylene performs well under high temperature conditions. These bottles are usually manufactured by injection-blow process, where molten plastic raw materials are injected into the mold by extrusion and injection, and then blown by high-pressure air to fully fill and mold the plastic raw materials into the precise shape of the bottle body. Ensure that the product has a consistent shape and excellent durability.

Specification and material introduction of plastic vaccine bottle

250ml PE plastic vaccine bottle

2. Product application: inactivated vaccines and vaccine diluents

Inactivated vaccines: including pseudorabies inactivated vaccines, blue ear disease inactivated vaccines, etc. These vaccines need to be stored in a stable environment to maintain their effectiveness. Veterinary vaccine bottles provide superior barrier and sealing properties, effectively protecting vaccines from the external environment and ensuring that vaccines remain efficient before use.

Vaccine diluents: Vaccines are usually in the form of freeze-dried vaccines, dry powder vaccines or liquid vaccines. For immunization, appropriate diluents are required. Vaccine diluent directly affects the effect of vaccination. Veterinary vaccine bottles can not only protect the stability of the diluent, but also ensure its safety and effectiveness during use.

3. Quality standards and guarantees

The quality standards of veterinary vaccine bottles are very strict, including appearance quality and characteristic indicators. Appearance quality ensures the integrity and non-contamination of the bottle mouth, bottle body and bottle bottom. The characteristic indicators cover multiple tests such as identification, sealing, drop resistance, water vapor permeability, etc. to ensure the stability, safety and reliability of the vaccine bottle. According to the group standard T/CVDA 4-2019 for veterinary liquid vaccine polyethylene bottles and veterinary liquid vaccine polyethylene bottles drafted and formulated by Shijiazhuang Xinfuda Pharmaceutical Packaging Co., Ltd., the details are as follows:

1. Bottle mouth: The end face of the bottle mouth should be flat, without chipping, and there should be no blocking defects in the bottle mouth

2. Bottle body: Fully formed, uniform color, no obvious color difference, no sand eyes, no oil stains, no bubbles, no deformation, no obvious shrinkage, no obvious scratches

3. Bottle bottom: The bottle can stand steadily

4. Identification: It should be basically consistent with the reference chart

5. Sealing: There should be no water ingress or bubbling in the bottle

6. Anti-drop: It should not break

7. Water vapor transmission: Not more than 0.2%

8. Ignition residue: ≤0.1% (the residue left by the bottle containing sunscreen is ≤3.0%)

9. Dissolution test

1) Clarity: The solution should be clear; if turbid, it should not be more concentrated than the No. 2 standard solution

2) pH change value: ≤1.0

3) Heavy metals: not more than one part per million

4) Oxidizable substances: ≤1.5ml

5) Non-volatile matter: water ≤12.0mg

6) Absorbance: ≤0.10

10. Decolorization test: The color of the immersion solution should not be darker than the blank solution

11. Thermal stability: No obvious deformation and no cracks

12. Sterility: Sterile

13. Ethylene oxide residue: ≤1 µg/ml

14. Abnormal toxicity: No abnormal toxicity

Overall, veterinary vaccine bottles provide key support and guarantee for the storage and use of inactivated vaccines and vaccine diluents through their material selection, sophisticated production processes and strict quality control. As technology advances and needs change, this packaging will continue to evolve and innovate to meet the growing challenges and needs in the field of animal healthcare.


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